Interaction of Caffeine and Continuous Distending Airway Pressure in Neonatal Apnea

Jacob V. Aranda; Eugene W. Outerbridge; Teresa Trippenbach

doi:10.1055/s-2007-1000051

American Journal of Perinatology, Table of Contents

Am J Perinatol 1983; 1(1): 43-46
DOI: 10.1055/s-2007-1000051

ORIGINAL ARTICLE

Interaction of Caffeine and Continuous Distending Airway Pressure in Neonatal Apnea

Jacob V. Aranda, Eugene W. Outerbridge, Teresa Trippenbach

Developmental Pharmacology and Perinatal Research Unit, Montreal Children's Hospital Research Institute, and Departments of Pediatrics, Physiology, Pharmacology, and Therapeutics, McGill University, Montreal, Quebec, Canada

Abstract

ABSTRACT

The interactive effect of caffeine and continuous distending airway pressure was evaluated in two premature neonates with apnea. The application of a continuous negative pressure around the chest wall decreased minute ventilation in both infants and blunted the stimulatory effect of caffeine. This potential interaction should be considered if the desired effects of caffeine or distending airway pressure on apnea control are not achieved when they are used concurrently.

Full Text