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J Reconstr Microsurg 1998; 14(6): 397-399
DOI: 10.1055/s-2007-1000198
ORIGINAL ARTICLE

© 1998 by Thieme Medical Publishers, Inc.

Free‐Flap Evolution after Hyperthermic Regional Chemotherapy in the Isolated Limb for Malignant Melanoma

D. Goldschmidt, J. Van Geertruyden, S. de Fontaine
  • Department of Plastic Surgery, University Hospital Erasme, Brussels, Belgium
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Publication History

Accepted for publication 1998

Publication Date:
08 March 2008 (online)

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ABSTRACT

Two patients presenting with a stage I melanoma of the sole of the foot (Clark's level IV, Breslow's 2.8 mm, and Clark's level IV, Breslow's 3.2 mm) underwent a 3-cm tumor free-margin skin resection, followed by microanastomosed muscle flap reconstruction (serratus anterior and latissimus dorsi). Immediately after primary wound healing, an elective inguino-iliac lymph-node dissection, followed by hyperthermic isolated regional chemotherapy with Melphalan, was carried out. Only moderate swelling of both free flaps was observed after these procedures, and this resolved rapidly. The patients returned to ambulation after 2 weeks. No other side effects of the hyperthermic isolated regional chemotherapy were observed in the previously microanastomosed flaps.