J Reconstr Microsurg 1995; 11(6): 455-459
DOI: 10.1055/s-2007-1006560
ORIGINAL ARTICLE

© 1995 by Thieme Medical Publishers, Inc.

A Standardized Model of Microvenous Thrombosis

Martin B. Hirigoyen, Wen X. Zhang, Hubert Weinberg
  • Division of Plastic Surgery, Department of Surgery, Mount Sinai Hospital, New York
Further Information

Publication History

Accepted for publication 1995

Publication Date:
08 March 2008 (online)

ABSTRACT

A standardized model of venous thrombosis is necessary when evaluating potential antithrombotic or thrombolytic agents in microsurgery. Previous studies have shown the adventitial “tuck” model to be advantageous in terms of the vascular reactivity achieved and the relative ease of performance. However, variability exists in the current design, due to the lack of standardized dimensions of the adventitial flap. Two variations of this model are presented which attempt to overcome this problem, and their reproducibility is compared to the inversion graft model of venous thrombosis in the rat femoral vein. The “femoral vein flap” is suggested as a suitable model to simulate anastomotic thrombosis during microvenorrhaphy.