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Exp Clin Endocrinol Diabetes 2007; 115(5): 334-338
DOI: 10.1055/s-2007-961796
Case Report

© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New York

Severe Cognitive Dysfunction in a Patient with Polyendocrinopathy

M. Siavash Dastjerdi 1 , A. Aminorroaya 1 , M. Amini 1 , F. Ashrafi 1 , F. Kazemi 1 , M. Saadatnia 1 , P. Mottaghi 1 , A. Emami 1
  • 1Isfahan Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Further Information

Publication History

received 11. 4. 2006 first decision 28. 6. 2006

accepted 4. 12. 2006

Publication Date:
21 May 2007 (online)

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Abstract

Background: Polyglandular Autoimmune syndromes (PGAs) or polyendocrinopathies are immune mediated multiple endocrine gland failure sometimes accompanied by nonendocrine autoimmune disorders with varieties of presentations.

Case report: We describe a case of a middle aged man with severe cognitive dysfunction, brain atrophy, adrenal insufficiency, hypothyroidism, renal failure, thrombocytopenia, and positive antiphospholipid antibodies, with significant renal and cognitive improvement after hormone replacement.

Conclusions: PGAs may present with a broad spectrum of manifestations related to different organs like nervous,renal,cardiac and hematopoietic systems, sometimes challenging both to physician and the patient.

Key words

polyglandular autoimmune syndrome - adrenal insufficiency - dementia - antiphospholipid antibody syndrome

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Correspondence

M. S. Dastjerdi

Isfahan Endocrine & Metabolism Research Center

Sedigheh Tahereh Medical Research Complex

Khorram Street

Isfahan

Iran

Phone: 0098/311/335 99 33

Fax: 0098/311/337/37 33

Email: siavash@med.mui.ac.ir