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Horm Metab Res 2007; 39(2): 96-105
DOI: 10.1055/s-2007-961808
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© Georg Thieme Verlag KG Stuttgart · New York

Nuclear Hormone Receptors in Human Skin

M. Schmuth 1 , R. E. Watson 2 , D. Deplewski 3 , S. Dubrac 1 , C. C. Zouboulis 4 , 5 , C. E. Griffiths 2
  • 1Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
  • 2Dermatology Centre, Hope Hospital, University of Manchester, Salford, Manchester, UK
  • 3Department of Pediatrics, Section of Pediatric Endocrinology, The University of Chicago Pritzker School of Medicine, Comer Children's Hospital, Chicago, IL, USA
  • 4Departments of Dermatology and Immunology, Dessau Medical Center, Dessau, Germany
  • 5Laboratory of Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charité Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Further Information

Publication History

received 4. 12. 2006

accepted 21. 12. 2006

Publication Date:
27 February 2007 (online)

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Abstract

Nuclear hormone receptors are of critical importance for skin homeostasis where they modulate cellular metabolism, proliferation, differentiation, cell death, and inflammation. The cutaneous role of the glucocorticoid, androgen, and estrogen receptors was explored initially. In recent years, sequence homology comparisons have uncovered the complete superfamily of related receptors, many of which are also implicated in cutaneous homeostasis. A subgroup of these receptors acts in concert with the retinoid X receptor by heterodimerization and has been successfully targeted for dermatologic therapy; i.e., the retinoic acid receptor and the vitamin D receptor. Ongoing research is aimed at delineating the cutaneous effects of additional members of this subgroup including the peroxisome proliferator-activated receptors and the liver X receptors. The various receptors exert differential effects in skin and can be rationally chosen as drug targets for the treatment of cutaneous pathologies.

Keywords

epidermis - inflammation - psoriasis - skin cancer - transcription factor

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Correspondence

M. Schmuth

Department of Dermatology·Innsbruck Medical University

Anichstr. 35

6020 Innsbruck

Phone: +43/512/504 29 971

Fax: +43/512/504 22 99 0

Email: matthias.schmuth@i-med.ac.at