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DOI: 10.1055/s-2007-963295
© Georg Thieme Verlag KG Stuttgart · New York
Molekulare Bildgebung der Apoptose bei kardiovaskulären Erkrankungen
Molecular Imaging of Apoptosis in Cardiovascular DiseasesPublication History
eingereicht: 14.12.2006
angenommen: 16.3.2007
Publication Date:
29 June 2007 (online)
![](https://www.thieme-connect.de/media/roefo/200708/lookinside/thumbnails/10.1055-s-2007-963295-1.jpg)
Zusammenfassung
Die molekulare Bildgebung funktioneller Parameter wie der Apoptose (programmierter Zelltod) in vivo eröffnet in der klinischen Diagnostik und wissenschaftlichen Forschung neue Dimensionen. Insbesondere bei kardiovaskulären Erkrankungen, die in westlichen Industrienationen hauptsächlich für Morbidität und Mortalität verantwortlich sind, sind neue nichtinvasive Untersuchungstechniken erforderlich, die eine frühzeitige Diagnose schwerwiegender Erkrankungen ermöglichen. Da Apoptose im Gegensatz zur Nekrose schon bei geringfügigen Alterationen des Mikroenvironments von Zellen auftreten und bei zahlreichen kardiovaskulären Erkrankungen eine Rolle spielen, gibt es bereits jetzt weltweit mehrere Forschungsansätze zur molekularen Bildgebung der Apoptose in vivo. In der vorliegenden Übersicht werden die Grundlagen der Apoptose beim Myokardinfarkt, Myokarditis, Atherosklerose, Restenosierung nach Angioplastie und Stentimplantation, bislang eingesetzte bildgebende Techniken, erzielte Resultate und zukünftige Perspektiven der molekularen Bildgebung der Apoptose dargestellt.
Abstract
Molecular imaging of functional parameters such as apoptosis (programmed cell death) in vivo opens new possibilities in clinical diagnostic and scientific research. Especially in the case of cardiovascular diseases that are mainly responsible for both morbidity and mortality in Western industrial nations, innovative non-invasive examination strategies are necessary for early diagnosis of these diseases. Since apoptosis unlike necrosis is present even after minor alterations of the microenvironment of cells and has been shown to be involved in a large number of cardiovascular diseases, there are currently several experimental studies underway with the goal of imaging apoptosis in vivo. The review discusses the basics of apoptosis in myocardial infarction, myocarditis, atherosclerosis, restenosis after angioplasty and stent implantation, currently used imaging techniques, achieved results, and future possibilities for molecular imaging of apoptosis.
Key words
cardiac - vascular - molecular imaging
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Dr. Ingrid Böhm
Radiolog. Universitätsklinik, Rheinische Friedrich-Wilhelms-Universität, Bonn
Sigmund-Freud Str. 25
53105 Bonn
Phone: ++49/2 28/2 87 96 31
Fax: ++49/2 28/2 87 44 57
Email: ingrid.boehm@ukb.uni-bonn.de