Abstract
Epidemiological evidence suggests that incidence of colorectal cancer can be reduced by 60 - 90 % among participants of preventive colonoscopy with removal of precancerous lesions. Even with sigmoidosopy, the majority of cancers can be prevented. Cost-effectiveness analyses suggest screening schemes based on colonoscopy every 10 years or on sigmoidoscopy every 5 years to be highly cost effective compared to other preventive measures. Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence.
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H. Brenner
Div. of Clinical Epidemiology and Aging Research, German Cancer Research Center
Bergheimer Straße 20
69115 Heidelberg, Germany
Phone: ++ 49/62 21/54 81 40
Fax: ++ 49/62 21/54 81 42
Email: H.Brenner@dkfz.de
