Zusammenfassung
Das Ovarialkarzinom ist das zweithäufigste Genitalmalignom der Frau und trägt wegen der häufig späten Diagnosestellung einen hohen Anteil an krebsbedingter Mortalität. In der Suche nach Risikofaktoren für ein Ovarialkarzinom rückt in letzter Zeit neben den häufigen klassischen und familiären Faktoren die Endometriose und das seltene Ovarian-Remnant-Syndrom zunehmend ins Bewusstsein. Wir schildern den Fall einer 49-jährigen Patientin mit Ovarialkarzinom nach vorausgegangener beidseitiger Adnektomie und diskutieren die möglichen kausalen Faktoren.
Abstract
Ovarian cancer is one of the most frequently occurring genital malign disorders in women and contributes hugely to cancer-caused mortality. In the search for risk factors for ovarian cancer interest has increasingly focused on endometriosis and the rare ovarian remnant syndrome. We report on a case of a 49-year-old patient with ovarian cancer after bilateral salpingo-ovariectomy and discuss possible causal factors.
Schlüsselwörter
Endometriose - Ovarian‐Remnant‐Syndrom - Ovarialkarzinom - extraovarielles Ovarialkarzinom - Unterbauchschmerzen
Key words
endometriosis - ovarian remnant syndrome - ovarian carcinoma - extraovarian ovarian carcinoma - lower abdominal pain
Literatur
-
1 Schmalfeldt (Hrsg) B. Maligne Ovarialtumoren. Tumorzentrum München. 7. Aufl. München, Wien, New York; Zuckschwerdt 2004
-
2
Kobayashi H, Sumimoto K, Moniwa N, Imai M, Takakura K, Kuromaki T, Morioka E, Arisawa K, Terao T.
Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan.
Int J Gynecol Cancer.
2007;
17
37-43
-
3
Valenzuela P, Ramos P, Redondo S, Cabrera Y, Alvarez I, Ruiz A.
Endometrioid adenocarcinoma of the ovary and endometriosis.
Eur J Obstet Gynecol Reprod Biol.
2006;
-
4
Narayansingh G, Cumming G, Parkin D, Miller I.
Ovarian cancer developing in the ovarian remnant syndrome. A case report and literature review.
Aust N Z J Obstet Gynaecol.
2000;
40
221-223
-
5
Dereska N H, Cornella J, Hibner M, Magrina J F.
Mucinous adenocarcinoma in an ovarian remnant.
Int J Gynecol Cancer.
2004;
14
683-686
-
6
Melin A, Sparen P, Persson I, Bergqvist A.
Endometriosis and the risk of cancer with special emphasis on ovarian cancer.
Hum Reprod.
2006;
21
1237-1242
-
7
Sampson J A.
Endometrial carcinoma of the ovary arising in endometrial tissue in that organ.
Arch Surg.
1925;
10
1-72
-
8
Borgfeldt C, Andolf E.
Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis.
Acta Obstet Gynecol Scand.
2004;
83
395-400
-
9
Brinton L A, Lamb E J, Moghissi K S, Scoccia B, Althuis M D, Mabie J E, Westhoff C L.
Ovarian cancer risk associated with varying causes of infertility.
Fertil Steril.
2004;
82
405-414
-
10
Modugno F, Ness R B, Allen G O, Schildkraut J M, Davis F G, Goodman M T.
Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis.
Am J Obstet Gynecol.
2004;
191
733-740
-
11
Dogan S, Agic A, Eilers W, Finas D, Diedrich K, Hornung D.
Endometriose und Malignomrisiko.
Geburtsh Frauenheilk.
2006;
66
739-744
-
12
Sainz de la Cuesta R, Eichhorn J H, Rice L W, Fuller Jr A F, Nikrui N, Goff B A.
Histologic transformation of benign endometriosis to early epithelial ovarian cancer.
Gynecol Oncol.
1996;
60
238-244
-
13
Vercellini P, Parazzini F, Bolis G, Carinelli S, Dindelli M, Vendola N, Luchini L, Crosignani P G.
Endometriosis and ovarian cancer.
Am J Obstet Gynecol.
1993;
169
181-182
-
14
Fukunaga M, Nomura K, Ishikawa E, Ushigome S.
Ovarian atypical endometriosis: its close association with malignant epithelial tumours.
Histopathology.
1997;
30
249-255
-
15
McMeekin D S, Burger R A, Manetta A, DiSaia P, Berman M L.
Endometrioid adenocarcinoma of the ovary and its relationship to endometriosis.
Gynecol Oncol.
1995;
59
81-86
-
16
Brinton L A, Gridley G, Persson I, Baron J, Bergqvist A.
Cancer risk after a hospital discharge diagnosis of endometriosis.
Am J Obstet Gynecol.
1997;
176
572-579
-
17
Swiersz L M.
Role of endometriosis in cancer and tumor development.
Ann N Y Acad Sci.
2002;
955
281-292
-
18
Prowse A H, Manek S, Varma R, Liu J, Godwin A K, Maher E R, Tomlinson I P, Kennedy S H.
Molecular genetic evidence that endometriosis is a precursor of ovarian cancer.
Int J Cancer.
2006;
119
556-562
-
19
Takeuchi M, Matsuzaki K, Uehara H, Nishitani H.
Malignant transformation of pelvic endometriosis: MR imaging findings and pathologic correlation.
Radiographics.
2006;
26
407-417
-
20
Shemwell R E, Weed J C.
Ovarian remnant syndrome.
Obstet Gynecol.
1970;
36
299-303
-
21
Magtibay P M, Magrina J F.
Ovarian remnant syndrome.
Clin Obstet Gynecol.
2006;
49
526-534
-
23
Kaminski P F, Sorosky J I, Mandell M J, Broadstreet R P, Zaino R J.
Clomiphene citrate stimulation as an adjunct in locating ovarian tissue in ovarian remnant syndrome.
Obstet Gynecol.
1990;
76
924-926
-
24
Magtibay P M, Nyholm J L, Hernandez J L, Podratz K C.
Ovarian remnant syndrome.
Am J Obstet Gynecol.
2005;
193
2062-2066
-
25
Brühwiler H, Luscher K P.
Ovarialkarzinom bei Ovarian Remnant Syndrome.
Geburtsh Frauenheilk.
1991;
51
70-71
-
26
Glaser D, Burrig K F, Mast H.
Ovarialkarzinom bei Ovarian Remnant Syndrome?.
Geburtsh Frauenheilk.
1992;
52
436-437
-
27
Le Bouedec G, Bailly C, De Lapasse C, Gimbergues P, Dauplat J.
Retained ovarian remnant carcinoma: a case report.
J Gynecol Obstet Biol Repro.
2006;
35
829-833
Dr. Eugen Ruckhäberle
Zentrum für Gynäkologie und Geburtshilfe der Johann-Wolfgang-Goethe-Universität Frankfurt
Theodor-Stern-Kai 7
60590 Frankfurt
Email: eugen.ruckhaeberle@med.uni-frankfurt.de
