Synthesis of Substituted 2,2′-Bipyridines from 2-Bromo- or 2-Chloropyridines Using Tetrakis(triphenylphosphine)palladium(0) as a Catalyst in a Modified Negishi Cross-Coupling Reaction

U. Kiehne; J. Bunzen; H. Staats; A. Lützen

doi:10.1055/s-2007-965952

PAPER

Synthesis of Substituted 2,2′-Bipyridines from 2-Bromo- or 2-Chloropyridines Using Tetrakis(triphenylphosphine)palladium(0) as a Catalyst in a Modified Negishi Cross-Coupling Reaction

U. Kiehne, J. Bunzen, H. Staats, A. Lützen*
University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany
Fax: +49(228)739608; e-Mail: arne.luetzen@uni-bonn.de;

Abstract

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Abstract

A protocol for an efficient, modified Negishi cross-coupling strategy for substituted 2,2′-bipyridines employing tetrakis(triphenylphosphine)palladium(0) as a simple, commercially available, and relatively inexpensive catalyst for both 2-bromo- and 2-chloropyridines has been developed. Further transformations were carried out yielding some new valuable functionalized 2,2′-bipyridines.

Key words

Negishi reaction - 2,2′-bipyridines - cross-coupling reactions - organozinc compounds - palladium

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References

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