Buchwald-Hartwig Amination of β-Chloroacroleins by Lactams and Heteroarylamines

Stéphanie Hesse; Gilbert Kirsch

doi:10.1055/s-2007-966034

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Buchwald-Hartwig Amination of β-Chloroacroleins by Lactams and Heteroarylamines

Stéphanie Hesse*, Gilbert Kirsch
Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, Université Paul Verlaine-Metz, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)873158 01; e-Mail: hesse@univ-metz.fr;

Abstract

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Abstract

β-Chloroacroleins reacted readily with lactams and several heteroarylamines (aminopyridines, aminoquinoline and azoles) under standard Buchwald-Hartwig amination conditions. Both Pd(OAc)₂/Binap or Pd(OAc)₂/Xantphos were efficient catalytic systems in the presence of Cs₂CO₃ as base.

Key words

palladium catalysis - amination - lactams - aminopyridines - azoles

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