Download PDF
Synthesis 2007(10): 1471-1474  
DOI: 10.1055/s-2007-966044
PAPER
© Georg Thieme Verlag Stuttgart · New York

A New Chemoselective Synthesis of Brombuterol

Marcelo S. Nery, Mariangela S. Azevedo, Jari N. Cardoso, Glaucia B. C. Slana, Rosangela S. C. Lopes*, Cláudio C. Lopes*
Departamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, CT, Bloco A, 5o andar, Rio de Janeiro, RJ, CEP 21949 900, Brazil
Fax: +55(21)25627854; e-Mail: claudiosabbatini@uol.com.br;
Further Information

Publication History

Received 21 December 2006
Publication Date:
02 May 2007 (online)

    Permissions and Reprints All articles of this category

Corrected by:

A New Chemoselective Synthesis of BrombuterolSynthesis 2016; 48(03): 462-462
DOI: 10.1055/s-0035-1560401

Abstract

A practical method for the synthesis of brombuterol [1-(4-amino-3,5-dibromophenyl)-2-(tert-butylamino)ethanol] in high overall yield is described starting from 4′-aminoacetophenone using a new chemoselective route.

Key words

β-agonists - chemoselective - bromination - brombuterol - clembuterol