A 56-year-old man with schizophrenia presented with acute hematemesis. He had been
taking nonsteroidal anti-inflammatory drugs frequently for headache. Emergency panendoscopy
revealed a huge gastric ulcer on the posterior wall, high in the body of the stomach.
The ulcer had a large visible vessel in its base. The vessel was coated with red clot
but there was active oozing under the clot ([Figure 1]).
Figure 1 Endoscopic view showing the giant ulcer base on the posterior wall high in the body
of the stomach. There was a large visible vessel coated by a red clot but with active
oozing.
Considering the firm ulcer base and the large vessel, a clipping device was used to
place two endoclips on both ends of the vessel. This did not stop the oozing, however.
Despite various measures, including injection of saline and epinephrine, and repeated
thermocoagulation with heater probe, bipolar hot biopsy forceps, and argon plasma
coagulation, the oozing could not be stopped. Band ligation was not considered for
the firm ulcer base. Eventually the bleeding was stopped by injection of 4 mL of a
mixture of equal amounts of N-butyl-2-cyanoacrylate (Histoacryl; B. Braun, Melsungen,
Germany) and Lipiodol (Laboratoire Guerbet, Aulnay-Sous-Bois, France). Although immediate
hemostasis was achieved, massive hematemesis recurred 2 days later. The patient underwent
surgery, when a giant penetrating ulcer extending to the liver bed was found. Moreover,
an incidental finding of portal vein embolization was made when a computed tomographic
scan was performed for the investigation of postoperative fever ([Figure 2]).
Figure 2 Computed tomography revealed the embolized portal vein was filled with radio-opaque
material, which had been caused by a mixture of Histoacryl and Lipiodol.
Numerous trials have demonstrated the benefit of endoscopic intervention compared
with medical management alone for acute nonvariceal upper gastrointestinal hemorrhage
[1]. Endoscopic treatment modalities can be categorized into three groups: injection,
thermal, and mechanical [2]. What is the cost of hemostasis using these treatments, however? Can they damage
adjacent organs?
Histoacryl injection for the treatment of varices is well established, despite its
complications [3]
[4], and it is used as a last resort before surgery in ulcer bleeding [5]. Vascular complications have rarely been reported. This case highlights the possibility
of unnecessary iatrogenic embolization of an adjacent organ while treating a huge
and deep ulcer.
Endoscopy_UCTN_Code_CPL_1AH_2AC
