Synlett 2007(4): 0652-0654  
DOI: 10.1055/s-2007-967980
LETTER
© Georg Thieme Verlag Stuttgart · New York

One-Pot Synthesis of Primary tert-Alkylamines by the Addition of Organometallic Reagents to Nitriles Mediated by Ti(Oi-Pr)4

Olesya Tomashenkoa, Viktor Sokolov*a, Alexander Tomashevskiya, Armin de Meijere*b
a Saint-Petersburg State University, Chemical Department, Universitetsky Pr. 26, 198504 Saint-Petersburg, Russian Federation
b Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen, Germany
Fax: +49(551)399475; e-Mail: ameijer1@gwdg.de;
Further Information

Publication History

Received 15 December 2006
Publication Date:
21 February 2007 (online)

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Abstract

A number of primary tert-alkylamines (18 examples, 25-72% yields) have been prepared according to a simple one-pot procedure by the addition of organometallic reagents such as Grignard reagents and organolithium compounds to nitriles in the presence of Ti(Oi-Pr)4.