ABSTRACT
Pancreatic islet cell transplantation is an evolving treatment of severe, refractory type 1 diabetes that has been gaining more use, particularly after one year rates of insulin independence post-transplantation were found to approach 80% under the Edmonton protocol. Islet cell transplantation involves percutaneous delivery of harvested allogeneic β cells into the portal venous circulation for implantation into the liver. We present the case of a 35-year-old woman with type 1 diabetes and situs ambiguous with left isomerism and resultant variant anatomy of her portal venous anatomy who underwent islet cell transplantation, which, to our knowledge, has not been previously reported.
KEYWORDS
Pancreatic islet cell transplantation - situs ambiguous - treatment of diabetes mellitus
REFERENCES
-
1 NIDDK .National Diabetes Statistics. 2005 Available at: http://diabetes.niddk.nih.gov/dm/pubs/statistics/
-
2
Morel P, Chau C, Brayman K et al..
Quality of metabolic control at 2 to 12 years after a pancreas transplant.
Transplant Proc.
1992;
24
835-838
-
3 Brendel M D, Hering B, Schultz A O, Bretzel R G. International Islet Transplant Registry. Newsletter 8. Giessen, Germany; Justus-Liebig University of Giessen 2001
-
4
Shapiro A M, Lakey J R, Paty B W, Senior P A, Bigam D L, Ryan E A.
Strategic opportunities in clinical islet transplantation.
Transplantation.
2005;
79
1304-1307
-
5
Fulcher A S, Turner M A.
Abdominal manifestations of situs anomalies in adults.
Radiographics.
2002;
22
1439-1456
-
6
Shapiro A M, Lakey J RT, Ryan E A et al..
Islet transplantation in seven patients with type-1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
N Engl J Med.
2000;
343
230-238
-
7
Shapiro A M, Ricordi C, Hering B J et al..
International trial of the Edmonton protocol for islet transplantation.
N Engl J Med.
2006;
355
1318-1330
-
8
Ryan E A, Pay B W, Senior P A et al..
Five-year follow-up after clinical islet transplantation.
Diabetes.
2005;
54
2060-2069
-
9
Atri M, Bret P M, Fraser-Hill M A.
Intrahepatic portal venous variations: prevalence with US.
Radiology.
1992;
184
157-158
-
10
Kodama Y, Shimizu T, Endo H, Miyamoto N, Miyasaka K.
Complications of percutaneous transhepatic portal vein embolization.
J Vasc Interv Radiol.
2002;
13
1233-1237
-
11
Venturini M, Angeli E, Maffi P et al..
Technique, complications, and therapeutic efficacy of percutaneous transplantation of human pancreatic islet cells in type 1 diabetes: the role of US.
Radiology.
2005;
234
617-624
Rajesh ShahM.D.
Department of Radiology, University of Illinois Medical Center at Chicago
1740 West Taylor Street, MC 931, Chicago, IL 60612
