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DOI: 10.1055/s-2007-982064
© Georg Thieme Verlag KG Stuttgart · New York
Das humane Bocavirus: Erreger von Atemwegsinfektionen?
The human bocavirus: Pathogen in airway infections?Publication History
eingereicht: 12.3.2007
akzeptiert: 14.6.2007
Publication Date:
03 July 2007 (online)

Zusammenfassung
Das humane Bocavirus (HBoV) wurde erstmals 2005 von Allander et al. beschrieben. Es handelt sich um ein humanpathogenes Parvovirus, das weltweit verbreitet zu sein scheint und vornehmlich im Säuglings- und Kleinkindalter mit Infektionen der Atemwege assoziiert ist. Die hier vorliegende Übersicht diskutiert anhand der bis Februar 2007 publizierten Studien das HBoV aus klinischer Perspektive.
Summary
The human Bocavirus (HBoV), the second member of the parvovirus family, which displays pathogenicity in humans, has been described in 2005 by Allander et al.. It seems to be distributed worldwide and has been isolated mainly in infants and children with respiratory tract infection. This review covers all studies published on HBoV to February 2007 and discusses this emerging viral pathogen from the perspective of inpatient medical treatment centers.
Schlüsselwörter
humanes Bocavirus - Atemwegsinfektion - hospitalisierte Kinder
Key words
human Bocavirus - respiratory tract infection - hospitalized infants and children
Literatur
- 1
Allander T, Jartti T, Gupta S. et al .
Human bocavirus and acute wheezing in children.
Clin Infect Dis.
2007;
44
904-910
MissingFormLabel
- 2
Allander T, Tammi M T, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B.
Cloning of a human parvovirus by molecular screening of respiratory tract samples.
Proc Natl Acad Sci U S A.
2005;
102
12891-12896
MissingFormLabel
- 3
American Academy of Pediatrics .
Diagnosis and management of bronchiolitis.
Pediatrics.
2006;
118
1774-1793
MissingFormLabel
- 4
Arnold J C, Singh K K, Spector S A, Sawyer M H.
Human bocavirus: prevalence and clinical spectrum at a children’s hospital.
Clin Infect Dis.
2006;
43
283-288
MissingFormLabel
- 5
Bastien N, Brandt K, Dust K, Ward D, Li Y.
Human Bocavirus infection, Canada.
Emerg Infect Dis.
2006;
12
848-850
MissingFormLabel
- 6
Choi E H, Lee H J, Kim S J. et al .
The association of newly identified respiratory viruses with lower respiratory tract
infections in Korean children, 2000 - 2005.
Clin Infect Dis.
2006;
43
585-592
MissingFormLabel
- 7
Donnelly L F.
Imaging in immunocompetent children who have pneumonia.
Radiol Clin North Am.
2005;
43
253-265
MissingFormLabel
- 8
Donnelly L F.
Practical issues concerning imaging of pulmonary infection in children.
J Thorac Imaging.
2001;
16
238-250
MissingFormLabel
- 9
Fitzgerald D A, Kilham H A.
Bronchiolitis: assessment and evidence-based management.
Med J Aust.
2004;
180
399-404
MissingFormLabel
- 10
Foulongne V, Olejnik Y, Perez V, Elaerts S, Rodiere M, Segondy M.
Human bocavirus in French children.
Emerg Infect Dis.
2006;
12
1251-1253
MissingFormLabel
- 11
Foulongne V, Rodiere M, Segondy M.
Human Bocavirus in children.
Emerg Infect Dis.
2006;
12
862-863
MissingFormLabel
- 12
Fry A M, Lu X, Chittaganpitch M. et al .
Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring
hospitalization in Thailand.
J Infect Dis.
2007;
195
1038-1045
MissingFormLabel
- 13
Kaplan N, Dove W, Abu-Zeid A. et al .
Human Bocavirus Infection among Children, Jordan.
Emerg Infect Dis.
2006;
12
1419-1420
MissingFormLabel
- 14
Kesebir D, Vazquez M, Weibel C. et al .
Human bocavirus infection in young children in the United States: molecular epidemiological
profile and clinical characteristics of a newly emerging respiratory virus.
J Infect Dis.
2006;
194
1276-1282
MissingFormLabel
- 15
Kleines M, Scheithauer S, Rackowitz A, Ritter K, Hausler M.
High prevalence of human bocavirus detected in young children with severe acute lower
respiratory tract disease using a standard PCR protocol and a novel real time PCR
protocol.
J Clin Microbiol.
2007;
45 (3)
1032-1034
MissingFormLabel
- 16
Korppi M.
Community-acquired pneumonia in children: issues in optimizing antibacterial treatment.
Paediatr Drugs.
2003;
5
821-832
MissingFormLabel
- 17
Korppi M.
Mixed microbial aetiology of community-acquired pneumonia in children.
Apmis.
2002;
110
515-522
MissingFormLabel
- 18
Kupfer B, Vehreschild J, Cornely O. et al .
Severe Pneumonia and Human Bocavirus in an Adult.
Emerg Infect Dis.
2006;
12
1614-1616
MissingFormLabel
- 19
Lin F, Zeng A, Yang N. et al .
Quantification of human bocavirus in lower respiratory tract infections in China.
Infect Agent Cancer.
2007;
2
3
MissingFormLabel
- 20
Lu X, Chittaganpitch M, Olsen S J. et al .
Real-time PCR assays for detection of bocavirus in human specimens.
J Clin Microbiol.
2006;
44
3231-3235
MissingFormLabel
- 21
Ma X, Endo R, Ishiguro N. et al .
Detection of human bocavirus in Japanese children with lower respiratory tract infections.
J Clin Microbiol.
2006;
44
1132-1134
MissingFormLabel
- 22
Manning A, Russell V, Eastick K. et al .
Epidemiological profile and clinical associations of human bocavirus and other human
parvoviruses.
J Infect Dis.
2006;
194
1283-1290
MissingFormLabel
- 23
McIntosh K.
Community-acquired pneumonia in children.
N Engl J Med.
2002;
346
429-437
MissingFormLabel
- 24
Meissner H C.
Selected populations at increased risk from respiratory syncytial virus infection.
Pediatr Infect Dis J.
2003;
22
S40-4; discussion S44 - 45
MissingFormLabel
- 25
Ogra P L.
Respiratory syncytial virus: the virus, the disease and the immune response.
Paediatr Respir Rev.
2004;
(Suppl A)
5
S119-126
MissingFormLabel
- 26
Openshaw P J, Tregoning J S.
Immune responses and disease enhancement during respiratory syncytial virus infection.
Clin Microbiol Rev.
2005;
18
541-555
MissingFormLabel
- 27
Panitch H B.
Viral respiratory infections in children with technology dependence and neuromuscular
disorders.
Pediatr Infect Dis J.
2004;
23
S222-227
MissingFormLabel
- 28
Regamey N, Frey U, Deffernez C, Latzin P, Kaiser L.
Isolation of human Bocavirus from Swiss infants with respiratory infections.
Pediatr Infect Dis J.
2007;
26
177-179
MissingFormLabel
- 29
Schenk T, Huck B, Forster J, Berner R, Neumann-Haefelin D, Falcone V.
Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized
for lower respiratory tract infection.
Eur J Clin Microbiol Infect Dis.
2007;
26
147-149
MissingFormLabel
- 30
Simoes E A.
Environmental and demographic risk factors for respiratory syncytial virus lower respiratory
tract disease.
J Pediatr.
2003;
143
S118-126
MissingFormLabel
- 31
Simon A, Groneck P, Kupfer B. et al .
Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis.
J Infect.
2007;
54
e125-127
MissingFormLabel
- 32
Simon A, Khurana K, Wilkesmann A. et al .
Nosocomial respiratory syncytial virus infection: Impact of prospective surveillance
and targeted infection control.
Int J Hyg Environ Health.
2006;
209
317-324
MissingFormLabel
- 33
Sloots T P, McErlean P, Speicher D J, Arden K E, Nissen M D, Mackay I M.
Evidence of human coronavirus HKU1 and human bocavirus in Australian children.
J Clin Virol.
2006;
35
99-102
MissingFormLabel
- 34
Smuts H, Hardie D.
Human Bocavirus in hospitalized children, South Africa.
Emerg Infect Dis.
2006;
12
1457-1458
MissingFormLabel
- 35
Smyth R L, Openshaw P J.
Bronchiolitis.
Lancet.
2006;
368
312-322
MissingFormLabel
- 36
Völz S, Schildgen O, Klinkenberg D. et al .
Prospective study of human Bocavirus (HBoV) infection in a pediatric university hospital
in Germany 2005/2006.
J Clin Virol.
2007;
submitted
MissingFormLabel
- 37
Weigl J A, Puppe W, Schmitt H J.
Can respiratory syncytial virus etiology be diagnosed clinically? A hospital-based
case-control study in children under two years of age.
Eur J Epidemiol.
2003;
18
431-439
MissingFormLabel
- 38
Weissbrich B, Neske F, Schubert J. et al .
Frequent detection of bocavirus DNA in German children with respiratory tract infections.
BMC Infect Dis.
2006;
6
109
MissingFormLabel
- 39
Wilkesmann A, Schildgen O, Eis-Hubinger A M. et al .
Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory
syncytial virus infections.
Eur J Pediatr.
2006;
165
467-475
MissingFormLabel
- 40
Wilkesmann A, Schildgen O, Eis-Hubinger A M, Lentze M J, Bode U, Simon A.
Das humane Metapneumovirus als Erreger von Atemwegsinfektionen bei hospitalisierten
Kindern - eine Übersicht.
Klin Padiatr.
2007;
219 (2)
58-65
MissingFormLabel
- 41
Williams J V, Harris P A, Tollefson S J. et al .
Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants
and children.
N Engl J Med.
2004;
350
443-450
MissingFormLabel
Priv.-Doz. Dr. rer. nat. Oliver Schildgen
Institut für Virologie
Sigmund-Freud-Straße 25
53105 Bonn
Phone: 0228/28711697
Fax: 0228/28714433
Email: schildgen@mibi03.meb.uni-bonn.de