Abstract
A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aqueous conditions at room temperature is described. Treatment of an aqueous solution of a variety of primary amines with two equivalents of glyoxylic acid leads to the N -formyl glycine derivatives. Direct hydrolysis of the crude reaction solution leads to the products of amine monocarboxymethylation in good to excellent yield.
Key words
metal-free synthesis - amino acids - glycine derivatives
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