Efficient Synthesis of 2-Substituted 7-Azaindole Derivatives via Palladium-Catalyzed Coupling and C-N Cyclization Using 18-Crown-6

Marcos Carlos de Mattos; Sergio Alatorre-Santamaría; Vicente Gotor-Fernández; Vicente Gotor

doi:10.1055/s-2007-983730

PAPER

Efficient Synthesis of 2-Substituted 7-Azaindole Derivatives via Palladium-Catalyzed Coupling and C-N Cyclization Using 18-Crown-6

Marcos Carlos de Mattos, Sergio Alatorre-Santamaría, Vicente Gotor-Fernández, Vicente Gotor*
Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain
Fax: +34(98)5103448; e-Mail: vgs@fq.uniovi.es;

Abstract

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Abstract

A practical and straightforward preparation of various novel 2-substituted 7-azaindole derivatives from 2-amino-3-iodopyridine by a two-step procedure is described that gives the desired compounds in good overall yields.

Key words

alkynes - 7-azaindoles - 18-crown-6 - heterocycles - palladium catalysis

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Referenzen

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