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Synthesis 2007(17): 2614-2616  
DOI: 10.1055/s-2007-983843
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

An Efficient Entry to Amino-Substituted Resorcylic Acid Derivatives for the Synthesis of Platensimycin and Analogues

Philipp Heretsch, Athanassios Giannis*
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany
Fax: +49(0341)9736599; e-Mail: giannis@uni-leipzig.de;
Further Information

Publication History

Received 21 May 2007
Publication Date:
08 August 2007 (online)

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Abstract

An efficient entry to protected amino-substituted resorcylic acid derivatives, methyl 3- or 5-amino-2,4-bis(methoxy­methoxy)benzoate, is reported. Both derivatives can be used for the synthesis of platensimycin and its analogues.

Key words

amino-resorcylic acid - antibiotic - arene - natural products - platensimycin

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