Synthesis and Antiviral Evaluation of Sugar Uracil-1-ylmethylhydrazones and Their Oxadiazoline Derivatives

Abstract

1-Carbethoxymethyluracils have been synthesized and derivatized to the corresponding hydrazides, which were reacted with monosaccharides to afford the corresponding sugar hydrazones. Acetylation of the latter with acetic anhydride in pyridine, afforded the per-O-acetyl derivatives, while heating in acetic anhydride gave the corresponding oxadiazolines. The prepared compounds were tested for antiviral activity against hepatitis B virus and showed moderate activities.

Key words

antiviral agents - carbohydrates - hydrazones - nucleobases - nucleosides

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