Pharmacopsychiatry 2007; 40(4): 169-170
DOI: 10.1055/s-2007-984388
Letter

© Georg Thieme Verlag KG Stuttgart · New York

Hypomania Induced by Atypical Antipsychotics among Schizophrenic Patients: Report of Three Cases

L. Baldaçara 1 , 2 , M. C. de Castro Ferrari 1 , B. F. Monteiro 1 , R. R. Uchida 1 , M. Sanches 1
  • 1Division of General Adult Psychiatry, Department of Psychiatry, Santa Casa de São Paulo School of Medicine, São Paulo, Brazil
  • 2Laboratório Interdisciplinar de Neurociências Clínicas (LINC) - Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Federal University of São Paulo, Brazil
Further Information

Publication History

received 05.02.2007 revised 30.04.2007

accepted 21.05.2007

Publication Date:
10 August 2007 (online)

Induction of mania or hypomania related to the use of atypical antipsychotics among patients with no history of mood disorders has been previously reported. We reported the cases of three schizophrenic patients with no previous history of mood disorders (including no history of mania or hypomania episodes) who developed hypomania associated to the use of atypical antipsychotics.

References

  • 1 Aubry JM, Simon AE, Bertschy G. Possible induction of mania and hypomania by olanzapine and risperidone: a critical review of reported case.  J Clin Psychiatry. 2000;  61 649-665
  • 2 Ichikawa J, Ishii H, Bonaccorso S. et al . 5-HT2a and D2 receptor blockade increases cortical DA release via 5-HT1a receptor activation: a possible mechanism of action of atypical antipsychotic-induced cortical dopamine release.  J Neurochem. 2001;  76 1521-1531
  • 3 Murphy BP. Amisulpride-induced mania in a patient with schizophrenia.  Br J Psychiatry. 2003;  183 172
  • 4 Rachid F, Bertschy G, Bondolfi G, Aubry JM. Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.  J Clin Psychiatry. 2004;  65 1537-1545
  • 5 Traber R, Schneiter R, Modestin J. A case of aripiprazole-induced mania.  Pharmacopsychiatry. 2007;  40 37-38

Correspondence

M. SanchesMD, PhD 

Division of General Adult Psychiatry

Department of Psychiatry

Santa Casa de São Paulo School of Medicine

241 Major Maragliano St.

São Paulo SP

04017-030 Brazil

Email: marsalsanches@terra.com.br