Synlett 2007(13): 2139-2141  
DOI: 10.1055/s-2007-984887
LETTER
© Georg Thieme Verlag Stuttgart · New York

The Chromium(II)-Mediated Coupling of Secondary Alkylhalides with Aromatic Aldehydes

Ludger A. Wessjohann*a, Gisela Schmidta, Henri S. Schrekker*a,b
a Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany
Fax: +49(345)55821309; e-Mail: wessjohann@ipb-halle.de;
b Laboratory of Technological Processes and Catalysis, Institute of Chemistry, UFRGS, Bento Gonçalves 9500, Porto Alegre-RS, CEP 91501-970, P.O. Box 15003, Brazil
Fax: +55(51)33087304; e-Mail: schrekker@iq.ufrgs.br;
Further Information

Publication History

Received 31 May 2007
Publication Date:
12 July 2007 (online)

Abstract

The scope of chromium(II)-mediated Takai-Utimoto ­reactions was extended to previously unconvertable secondary alkylhalides. Optimization allowed yields of up to over 95%.