Synlett 2007(13): 2111-2115  
DOI: 10.1055/s-2007-984899
LETTER
© Georg Thieme Verlag Stuttgart · New York

Phenanthridinium as an Artificial DNA Base: Comparison of Two Alternative Acyclic 2′-Deoxyribose Substitutes

Linda Valis, Hans-Achim Wagenknecht*
Institute for Organic Chemistry, University of Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany
Fax: +49(941)94348020; e-Mail: achim.wagenknecht@chemie.uni-regensburg.de;
Further Information

Publication History

Received 18 May 2007
Publication Date:
17 July 2007 (online)

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Abstract

(S)-1-Amino-2,3-propanediol and (2S,3S)-2-amino-1,3-butanediol have been used as two different acyclic substitutes for 2′-deoxyriboside in order to synthetically incorporate the phenanthridinium chromophore of ethidium as an artificial DNA base. The comparison of the optical properties of one representative duplex bearing phenanthridinium attached to the two alternative acyclic linkers does not exhibit significant differences.