Skull Base 2007; 17(4): 265-268
DOI: 10.1055/s-2007-985195
CASE REPORT

Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Clival Pituitary Adenoma with Acromegaly: Case Report and Review of Literature

Harjinder S. Bhatoe1 , Narendra Kotwal2 , Sonia Badwal3
  • 1Department of Neurosurgery, Army Hospital (Research & Referral), Delhi Cantt, New Delhi, India
  • 2Department of Endocrinology, Army Hospital (Research & Referral), Delhi Cantt, New Delhi, India
  • 3Department of Pathology, Army Hospital (Research & Referral), Delhi Cantt, New Delhi, India
Further Information

Publication History

Publication Date:
19 July 2007 (online)

ABSTRACT

The pituitary develops as a result of complex, intricate, and precise neuro-embryological events in the sixth to eighth weeks of gestation. Some ectopic cell rests can become adenomatous. Rarely, these cell rests in the clivus can be the site of formation of adenoma. Our patient, a 35-year-old parous woman, was being treated for acromegaly, and imaging studies revealed a clival mass lesion. Trans-sphenoidal excision was done and immunohistochemistry revealed the tumor to be a growth hormone-secreting tumor.

REFERENCES

  • 1 Erdheim J. Über einen Hypophysentumor von ungewöhnlichem.  Sitz Beitr Pathol Anat. 1909;  46 233-240
  • 2 De Witte O, Massager N, Salmon I, Meyer S, Dooms G, Brotchi J. Ectopic prolactinoma in the clivus.  Acta Chir Belg. 1998;  98 10-13
  • 3 Hori A, Schmidt D, Rickels E. Pharyngeal pituitary: development, malformation and tumorigenesis.  Acta Neuropathol (Berl). 1999;  98 262-272
  • 4 McGrath P. Extrasellar adenohypophyseal tissue in the female.  Australas Radiol. 1970;  14 241-247
  • 5 Anand V K, Osborne M, Harkey H L. Infiltrative clival pituitary adenoma of ectopic origin.  Otolaryngol Head Neck Surg. 1993;  108 178-183
  • 6 Kawamata T, Kubo O, Kamikawa S, Hori T. Ectopic clival craniopharyngioma.  Acta Neurochir (Wien). 2002;  144 1221-1224
  • 7 Heitzmann A, Jan M, Sacks M, Lieberman A. Ectopic prolactinoma within the sphenoid sinus.  Neurosurgery. 1989;  24 279-282
  • 8 Mount S L, Taatjes D J, Trainer T D. Ultrastructural study of a pituitary adenoma (prolactinoma) within clivus using immunoelectron microscopy.  Ultrastruct Pathol. 1993;  17 637-642
  • 9 Shenker Y, Lloyd R V, Weatherbee L, Port F K, Grekin R J, Barkan A L. Ectopic prolactinoma in a patient with hyperparathyroidism and abnormal sellar radiography.  J Clin Endocrinol Metab. 1986;  62 1065-1069
  • 10 Wong K, Raisanen J, Taylor S L, McDermott M W, Wilson C B, Gutin P H. Pituitary adenoma as an unsuspected clival tumor.  Am J Surg Pathol. 1995;  19 900-903
  • 11 Masui T, Takahashi M, Sugimura H et al.. Pituitary prolactinoma mimicking tumor originating from the sphenoid sinus and clivus.  Radiat Med. 1996;  14 189-191

 Col.
Harjinder S BhatoeM.Ch. 

Department of Neurosurgery, Army Hospital (Research & Referral)

Delhi Cantt 110010, New Delhi, India

Email: hsbhatoe@indiatimes.com