Synlett, Table of Contents ACCOUNT © Georg Thieme Verlag Stuttgart · New York Synthesis of β-Lactams Using the Kinugasa Reaction Runa Pal, Subhash Chandra Ghosh, Koushik Chandra, Amit Basak*Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, IndiaFax: absk@chem.iitkgp.ernet.in; Recommend Article Abstract Buy Article All articles of this category Abstract The development of new strategies for the synthesis of β-lactams and their derivatives remains at the forefront of organic synthesis. The copper(I)-catalyzed cycloaddition of a terminal alkyne and a nitrone, the Kinugasa reaction, leading to the formation of a β-lactam has recently drawn to the attention of organic chemists because of its wide scope as well as interesting mechanism. This report aims to give an account of developments in this area with particular emphasis on asymmetric examples. 1 Introduction 2 Synthesis of β-Lactams Using the Kinusaga Reaction 3 Asymmetric Kinugasa Reaction 4 Intramolecular Kinugasa Reaction 5 Kinugasa Reactions under Click Chemistry Conditions 6 Proline-Mediated Kinugasa Reaction 7 Kinugasa Reaction in the Synthesis of Peptidomimetics 8 Conclusion Key words β-lactams - cycloadditions - alkynes - nitrones - Kinugasa reaction Full Text References References 1a Antibiotic Resistance: Origins, Evolution, Selection and Spread Chadwick DJ. Goode J. John Wiley & Sons; Chichester: 1997. 1b McGowan JE. Tenover FC. Nat. Rev. Microbiol. 2004, 2: 251 1c Schmidt FR. Appl. Microbiol. Biotechnol. 2004, 63: 335 2a Chain B. Nature 1991, 353: 492 2b Ellis-Pegler RB. N. Z. Med. J. 1986, 99: 546 3a Kuo D. Weidner J. Griffin P. Shah SK. Knight WB. Biochemistry 1994, 33: 8347 3b Edwards PD. Bernstein PR. Med. Res. 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