Planta Med 2007; 73(14): 1491-1494
DOI: 10.1055/s-2007-990247
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Diterpenoids from the Roots of Croton oblongifolius

Witoon Youngsa-ad1 , 2 , Nattaya Ngamrojanavanich2 , Chulabhorn Mahidol1 , 3 , Somsak Ruchirawat1 , 3 , 4 , Hunsa Prawat1 , 3 , Prasat Kittakoop1 , 3
  • 1Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand
  • 2Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • 3Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand
  • 4Chulabhorn Research Centre, Institute of Science and Technology for Research and Development, Mahidol University, Thailand
Further Information

Publication History

Received: March 26, 2007 Revised: September 11, 2007

Accepted: September 18, 2007

Publication Date:
18 October 2007 (online)

Abstract

Two new clerodane diterpenes, methyl 15,16-epoxy-3,13(16),14-ent-clerodatrien-18,19-olide-17-carboxylate (1) and dimethyl 15,16-epoxy-12-oxo-3,13(16),14-ent-clerodatriene-17,18-dicarboxylate (2), together with seven known compounds (3 - 9), were isolated from the roots of Croton oblongifolius. The isolated compounds showed only mild cytotoxic activity against HuCCA-1, KB, HeLa, MDA-MB231, and T47D cell lines with IC50 values ranging from 10 to 50 μg/mL.

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Dr. Prasat Kittakoop

Chulabhorn Research Institute

Vipavadee-Rangsit Highway

Bangkok 10210

Thailand

Phone: +66-(0)86-9755-777

Fax: +66-(0)25-740-622 ext.1513

Email: prasatkittakoop@yahoo.com