A Simple and Efficient Synthesis of New Mono- and Bis([1,2,4]-oxadiazol)-benzaldehyde Building Blocks

François Crestey; Cyril Lebargy; Marie-Claire Lasne; Cécile Perrio

doi:10.1055/s-2007-990834

PAPER

A Simple and Efficient Synthesis of New Mono- and Bis([1,2,4]-oxadiazol)-benzaldehyde Building Blocks

François Crestey^a, Cyril Lebargy^a, Marie-Claire Lasne^a, Cécile Perrio*^a,b
^a Laboratoire de Chimie Moléculaire et Thioorganique, CNRS UMR 6507, ENSICAEN, Université de Caen Basse-Normandie, 6 Boulevard Maréchal Juin, 14050 Caen Cedex, France
^b Groupe de Développements Méthodologiques en Tomographie par Emissions de Positons, UMR CEA 2E, Université de Caen Basse-Normandie, Centre Cyceron, 15 Boulevard Henri Becquerel, 14070 Caen Cedex, France
Fax: +33(2)31470275; e-Mail: perrio@cyceron.fr;

Abstract

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Abstract

An efficient approach to bis([1,2,4]-oxadiazol)benzaldehydes as well as the corresponding mono-benzaldehyde derivatives has been developed starting from benzamidoxime, which is readily obtained from 4-cyanobenzaldehyde. All these new compounds were synthesized in a high-yielding, five-step procedure with few and simple purifications.

Key words

mono- and bis-benzaldehyde - 1,2,4-oxadiazole - benzamidoxime - O-acylation - acetal deprotection

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References

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