Stereochemical Assignments for All Four Isomers of Dolaproine via Lactam Formation

Abstract

The stereochemistry of all four possible stereoisomers of dolaproine was established through the syntheses and spectral analyses of structurally rigid bicyclic lactams. In addition, discrepancies with an earlier report were discovered and corrections are provided.

Key words

dolastatin - dolaproine - auristatin - aldol reaction - lactam - stereochemical - coupling constant - NOE

References

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