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Synlett 2007(19): 3055-3057
DOI: 10.1055/s-2007-990964
DOI: 10.1055/s-2007-990964
LETTER
© Georg Thieme Verlag Stuttgart · New York
Tandem Conjugate Addition-Aldol Cyclization to give Optically Active 1-Aryl-1H-indenes via Asymmetric Pd2+-Catalyzed 1,4-Addition of Aryl-boronic Acids
Further Information
Received
19 September 2007
Publication Date:
08 November 2007 (online)
Publication History
Publication Date:
08 November 2007 (online)
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Abstract
An asymmetric 1,4-addition of arylboronic acids to β-(2-acylaryl)enones was carried out in aqueous isopropanol in the presence of a dicationic palladium(II) complex and HBF4. The palladium complexes of (S,S)-chiraphos gave optically active 1-aryl-1H-indenes of up to 97% ee via tandem 1,4-addition-aldol condensation.
Key words
arylboronic acids - dicationic palladium catalyst - asymmetric conjugate addition - indene - tandem reactions
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