Effect of Preeclampsia on Mortality, Intraventricular Hemorrhage, and Need For Mechanical Ventilation in Very Low-Birth-Weight Infants

David A. Paul; June Kepler; Kathleen H. Leef; Anthony Siscione; Charles Palmer; John L. Stefano

doi:10.1055/s-2007-993961

American Journal of Perinatology, Table of Contents

Am J Perinatol 1998; 15(6): 381-386
DOI: 10.1055/s-2007-993961

ORIGINAL ARTICLE

Effect of Preeclampsia on Mortality, Intraventricular Hemorrhage, and Need For Mechanical Ventilation in Very Low-Birth-Weight Infants

David A. Paul¹ , June Kepler¹ , Kathleen H. Leef¹ , Anthony Siscione² , Charles Palmer³ , John L. Stefano¹

¹Section of Neonatology, Department of Pediatrics, Christiana Care Health Systems, Newark, Delaware and Thomas Jefferson Medical College, Philadelphia, Pennsylvania
²Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Deleware
³Division of Newborn Medicine, Department of Pediatrics, Hershey Medical Center, Hershey, Pennsylvania

Abstract

ABSTRACT

Infants born to mothers with preeclampsia have been shown to have a reduction in intraventricular hemorrhage (IVH). The objective of this article is to investigate the relationship between preeclampsia, IVH, neonatal mortality, mechanical ventilation, and other potential confounding variables such as neutropenia and magnesium sulfate. Methods of research include review of infants <1500 g admitted to a single level III neonatal intensive care unit (NICU), n = 356. Infants born to mothers with preeclampsia were compared to those without maternal preeclampsia by univariate and multivariate analysis. Overall, 52 mothers were diagnosed with preeclampsia. After multivariate modeling, preeclampsia was not associated with a decrease in mechanical ventilation (odds ratio 0.5, 95% Cl 0.2-1.3), IVH (odds ratio 0.5, 0.1-1.9) or mortality (odds ratio 0.6, 0.2-1.9). In our population, after controlling for multiple confounding variables, including MgSO4, neutropenia and thrombocytopenia, there was no difference in the odds of mortality, IVH, or requirement for mechanical ventilation in infants born to mothers with preeclampsia as compared to infants born to mothers without preeclampsia.

Keywords

Preeclampsia - intraventricular hemorrhage - mechanical ventilation - mortality

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