Congenital Genitourinary Tract Abnormalities Following Cocaine Exposure in Utero

ABSTRACT

The purpose of this study was to review the clinical and ultrasound experience of renal tract abnormalities associated with cocaine exposure in utero. We undertook a 3-year chart review of all infants admitted to British Columbia's Children's Hospital neonatal intensive care unit and Sunny Hill Health Centre for Children in order to identify patients with the diagnostic code for maternal drug or substance use. There were 136 neonates with a positive history or urine drug screen. Renal ultrasound scans had been performed on 79 patients. Ultrasound abnormalities were found in 11 patients (14%) and included horseshoe kidney (2), unilateral abnormal small kidney (1), duplex kidney (1), and renal tract dilation (8). Clinical findings were glandular (2) and juxtaglandular (1) hypospadias with chordee. The patients with hypospadias did not have other abnormalities or abnormal renal ultrasound scans. In our population of infants exposed to cocaine in utero we detected an increased incidence of hypospadias and an increased incidence of renal tract abnormalities. We conclude that cocaine exposure in utero may well be a risk factor for renal tract anomalies. However, a larger, longer-term prospective study is necessary before definitive recommendations can be given for routine screening by ultrasound of all infants exposed to cocaine in utero.

Keywords

Cocaine exposure in utero - maternal drug abuse - genitourinary tract abnormalities - ultrasonography