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Am J Perinatol 1995; 12(6): 459-461
DOI: 10.1055/s-2007-994521
DOI: 10.1055/s-2007-994521
ORIGINAL ARTICLE
© 1995 by Thieme Medical Publishers, Inc.
Clinical Significance of Neurofibromatosis in Pregnancy
Further Information
Publication History
Publication Date:
04 March 2008 (online)
![](https://www.thieme-connect.de/media/ajp/199506/lookinside/thumbnails/10.1055-s-2007-994521-1.jpg)
ABSTRACT
Neurofibromatosis (NF) is a common genetic disease that affects multiple organ systems. We studied eight women with NF and the outcome of their 14 pregnancies. One patient and her fetus died of a massive intracranial hemorrhage as a result of ruptured glioblastoma of the basal ganglia. The incidence of live birth and preterm labor were 50% and 28.6%, respectively. One of 14 pregnancies (7.1%) resulted in spontaneous abortion. There was also one growth-retarded fetus in this series (7.1%). Perinatal implications of this disease and management guidelines are discussed.
Keywords
Neurofibromatosis - genetic disease - pregnancy