Am J Perinatol 1994; 11(1): 1-3
DOI: 10.1055/s-2007-994522
ORIGINAL ARTICLE

© 1994 by Thieme Medical Publishers, Inc.

Postpartum Myocardial Infarction in a Patient with Antiphospholipid Syndrome

John M. Thorp Jr. , Nancy C. Chescheir, Benjamin Fann
  • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, and Mountain Area Women's Health Service, Mountain Area Health Education Center, Asheville, North Carolina
Further Information

Publication History

Publication Date:
04 March 2008 (online)

ABSTRACT

Myocardial infarction in association with pregnancy in patients with the antiphospholipid syndrome has been reported once previously. Our patient, a 22-year-old multiparous woman, experienced a myocardial infarction in the postpartum period. She fulfilled the criteria for the diagnosis of the antiphospholipid syndrome (elevated anticardiolipin antibody levels, false-positive syphilis serology, history of deep vein thrombosis). Cardiac catheterization demonstrated appropriate central filling pressures, cardiac output of 7.14 L/min, and normal-appearing coronary arteries. She was treated with corticosteroids and indomethacin and recovered. Our article is relevant to clinical practice for the following reasons. First, it is the second time myocardial necrosis has been reported in a recently pregnant woman with the antiphospholipid syndrome. Second, the finding of normal-appearing coronary arteries at the time of catheterization lends credence to the hypothesis that either vasospasm or thombosis are the inciting events. We speculate on the utility of various treatment regimens.