Subscribe to RSS
DOI: 10.1055/s-2007-999586
© 1989 by Thieme Medical Publishers, Inc.
Drug Ingestion During Pregnancy: Infrequent Exposure in a Contemporary United States Sample
Publication History
Publication Date:
04 March 2008 (online)
ABSTRACT
Drug ingestion in a cohort of United States women proved consistently lower than in prior United States populations. Participating were 342 insulin-dependent diabetic and 387 control subjects who were enrolled before conception (76%) or no later than 21 days after conception (24%). Drug exposures were then recorded at entry and periodically throughout organogenesis (gestational weeks 6, 8,10). During gestational weeks 1 to 10, approximately two thirds of the subjects were exposed to no agent other than oral iron, oral vitamins, or insulin (diabetic subjects). The mean exposures in gestational weeks 1 to 10 were 0.72 ± 1.05 (SD) for diabetic women and 0.54 ± 0.96 for control subjects; throughout pregnancy, the mean exposures were 1.26 ± 1.66 and 1.58 ± 1.78, respectively. The low exposure frequency in this contemporary United States population is highly encouraging. However, it follows that collaborative cohort efforts may be necessary in order to assess teratogenicity of drugs because relatively few women are now exposed.