Urinary 19-Nor-Deoxycorticosterone and Deoxycorticosterone in Hypertensive Disease of Pregnancy

Dinesh M. Shah; Celso E. Gomez-Sanchez; Robert A. Knuppel; William K. Vaughn

doi:10.1055/s-2007-999749

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 1987; 4(2): 102-105
DOI: 10.1055/s-2007-999749

ORIGINAL ARTICLE

Urinary 19-Nor-Deoxycorticosterone and Deoxycorticosterone in Hypertensive Disease of Pregnancy

Dinesh M. Shah¹ , Celso E. Gomez-Sanchez² , Robert A. Knuppel² , William K. Vaughn¹

¹Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida
²Departments of Obstetrics and Gynecology and Internal Medicine, University of South Florida College of Medicine and The James A. Haley Veterans Hospital, Tampa, Florida

Abstract

ABSTRACT

Normal pregnancy and pre-eclampsia are associated with water and sodium retention. Therefore various mineralocorticoids have been evaluated in normal and abnormal pregnancies. This study reports the urinary free 19-nor-deoxycorticosterone (19-nor-DOC) and deoxycorticosterone (DOC) levels in normal pregnancy and in patients with pregnancy-induced hypertension. Levels of 19-nor-DOC and DOC were not significantly different between normal patients in the third trimester and women with pregnancy-induced hypertension at a comparable gestational age. The urinary excretion of 19-nor-DOC in pregnancy was noted to be significantly lower than that previously reported in normal male volunteers. There was a positive correlation between 19-nor-DOC excretion and increasing gestational age. These data are compatible with the view that 19-nor-DOC may not play a role in pregnancy-induced hypertension. However, a larger study of primigravid women, with and without, pre-eclampsia is needed to confirm this finding.

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