Synlett 2008(3): 438-442  
DOI: 10.1055/s-2008-1032069
LETTER
© Georg Thieme Verlag Stuttgart · New York

Electrochemical Carboxylation of α,α-Difluorotoluene Derivatives and Its Application to the Synthesis of α-Fluorinated Nonsteroidal Anti-Inflammatory Drugs

Yusuke Yamauchi, Tsuyoshi Fukuhara, Shoji Hara, Hisanori Senboku*
Laboratory of Organic Reaction, Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Fax: +81(11)7066555; e-Mail: senboku@eng.hokudai.ac.jp;
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Publication History

Received 12 November 2007
Publication Date:
23 January 2008 (online)

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Abstract

Electrochemical carboxylation of α,α-difluorotoluene derivatives resulted in an efficient fixation of carbon dioxide to give the corresponding α-fluorophenylacetic acids in good yields, and this reaction was successfully applied to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs (NSAIDs).

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