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Planta Med 2008; 74(6): 682-685
DOI: 10.1055/s-2008-1034287
Workshop - State of the art in clinical and preclinical studies EPs® 7630 (Umckaloabo®)
Mini Review
© Georg Thieme Verlag KG Stuttgart · New York

Extract of Pelargonium sidoides (EPs® 7630) Displays Anti-Infective Properties by Enhanced Phagocytosis and Differential Modulation of Host-Bacteria Interactions

Andreas Conrad1 , Uwe Frank1
  • 1Institute of Environmental Medicine and Hospital Epidemiology, University Medical Center Freiburg, Freiburg, Germany
History: This article is based on a presentation held during the workshop ”State of the art in clinical and preclinical studies with EPs® 7630 (Umckaloabo®)” at the 55th International Congress & Annual Meeting of the Society for Medicinal Plant Research in Graz, Austria on September 4th, 2007.
Further Information

Publication History

Received: October 9, 2007 Revised: December 13, 2007

Accepted: December 16, 2007

Publication Date:
01 February 2008 (online)

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Abstract

EPs® 7630 is an aqueous-ethanolic extract of the roots of Pelargonium sidoides that displays well-documented benefits in the treatment of upper respiratory tract infections (URTI). In vitro and animal investigations have revealed various anti-infective properties of EPs® 7630. The present review sums up recently published in vitro investigations that have shown positive effects on the activity of human peripheral blood phagocytes (PBP) and differential modulation of the interactions between group A streptococci and the host’s epithelial barrier.

Key words

Pelargonium sidoides DC - EPs® 7630 - Geraniaceae - upper respiratory tract infection (URTI) - phagocytosis - group A streptococci - adhesion

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Andreas Conrad, MD

Institute of Environmental Medicine and Hospital Epidemiology

University Medical Center Freiburg

Breisacher Str. 115B

79106 Freiburg

Germany

Phone: +49-761-270-8262

Fax: +49-761-270-8253

Email: andreas.conrad@uniklinik-freiburg.de