Planta Med 2008; 74(4): 432-437
DOI: 10.1055/s-2008-1034318
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

New Abietane Diterpenoids from the Mangrove Avicennia marina

Li Han1 , 2 , Xueshi Huang1 , Hans-Martin Dahse1 , Ute Moellmann1 , Susanne Grabley1 , Wenhan Lin2 , Isabel Sattler1
  • 1Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany
  • 2State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, Peoples Republic of China
Further Information

Publication History

Received: September 12, 2007 Revised: December 12, 2007

Accepted: January 24, 2008

Publication Date:
07 March 2008 (online)

Abstract

Phytochemical investigations of the twigs of Avicennia marina yielded three new abietane diterpenoids 11-hydroxy-8,11,13-abietatriene 12-O-β-xylopyranoside (1), and a pair of inseparable epimers 6Hα-11,12,16-trihydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial 11,6-hemiacetal (2) and 6Hβ-11,12,16-trihydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial 11,6-hemiacetal (3), as well as the new lignan (7′S ,8′R )-4,4′,9′-trihydroxy-3,3′,5,5′-tetramethoxy-7,8-dehydro-9-al-2,7′-cyclolignan (5), together with 6,11,12,16-tetrahydroxy-5,8,11,13-abitetetraen-7-one (4), lyoniresinol (6), lyoniresinol 9′-O-β-D-glucopyranoside (7), and diacetylmartynoside (8). Structure elucidation of the new compounds was accomplished by analysis of their spectroscopic data. Compounds 2 - 4 showed moderate cytotoxic and antimicrobial activities.

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Prof. Wenhan Lin

State Key Laboratory of Natural and Biomimetic Drugs

Peking University

Beijing 100083

Peoples Republic of China

Phone: Phone: +86-10-8280-6188

Fax: Fax: +86-10-8280-2724

Email: E-mail: whlin@bjmu.edu.cn

Dr. Isabel Sattler

Leibniz Institute for Natural Product Research and Infection Biology

Hans-Knöll-Institute

Beutenbergstr. 11a

07745 Jena

Germany

Phone: +49-3641-656-920

Fax: +49-3641-656-679

Email: isabel.sattler@hki-jena.de