Chemical Constituents from the Stem Bark of Trewia nudiflora L. and their Antioxidant Activities

Abstract

Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4-O-β-(6″-O-galloyl)-glucopyranoside (1), 4,4′-O-dimethylellagic acid 3-(2″-O-acetyl)-α-rhamnopyranoside (2), and ethyl O-β-(6′-galloyl)-glucopyranoside (3), together with eleven known ones, were isolated from the stem bark of Trewia nudiflora. Their structures were elucidated by means of 1D, 2 D NMR and HR-MS analyses. The antioxidant activities of these compounds were evaluated with the DPPH radical-scavenging assay. Compound 1 showed significant antioxidant activity. In addition, compounds 1, 2 and 3 rescued the H₂O₂-induced PC12 cell death at 0.4 μM in the MTT assay.

Trewia nudiflora - Euphorbiaceae - stem bark - antioxidant activities

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