Introduction
Allyltrimethylsilane is an important reagent for the synthesis
of homoallyl alcohols, ethers, amines, α,β-acetylenic
ketones, β,γ-unsaturated ketones, etc., which
are utilized as important building blocks for the synthesis of biologically
active molecules. The allylation of carbonyl compounds is one of
the most important C-C bond-forming reactions. The use
of allyltrimethylsilane opens a new facet in the allylation reaction.
The reaction of an allyltrimethylsilane with a carbonyl compound
under Lewis acid conditions or in the presence of fluoride ions,
known as the Sakurai-Hosomi reaction
[¹]
has
been extensively studied and applied successfully in organic synthesis.
In addition to allylation reactions, other reactions such as cyclization
[²]
or ring-opening reaction
[³]
are also carried out using
the reagent.
