A Concise Synthesis of Mono- and Polysubstituted and Diversely N-Function­alized Isoindolinones and Isoquinolones

Magali Lorion; Axel Couture; Eric Deniau; Pierre Grandclaudon

doi:10.1055/s-2008-1067125

PAPER

A Concise Synthesis of Mono- and Polysubstituted and Diversely N-Functionalized Isoindolinones and Isoquinolones

Magali Lorion^a,b, Axel Couture*^a,b, Eric Deniau^a,b, Pierre Grandclaudon^a,b
^a LCOP, Université des Sciences et Technologies de Lille 1, Bâtiment C3(2), 59655 Villeneuve d’Ascq, France
Fax: +33(3)20336309; e-Mail: axel.couture@univ-lille1.fr;
^b CNRS, UMR 8009 ‘Chimie Organique et Macromoléculaire’, 59655 Villeneuve d’Ascq, France

Abstract

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Abstract

A variety of differently substituted and diversely N-(sulfanyl)hydroxyalkyl functionalized isoindolinones and isoquinolones have been obtained by anionic cyclization of cyclic bromobenzyl or bromophenethylcarbamates and thiocarbamates.

Key words

lactams - carbanions - ring closure - ring opening - bicyclic compounds

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Referenzen

References

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A Concise Synthesis of Mono- and Polysubstituted and Diversely N-Function­alized Isoindolinones and Isoquinolones

A Concise Synthesis of Mono- and Polysubstituted and Diversely N-Functionalized Isoindolinones and Isoquinolones