Synthesis of Phosphaisocoumarin Acids via Me₃SiX-Mediated Dealkylation Reaction

Abstract

The dealkylation of phosphaisocoumarin esters was studied under various conditions. An effective way to synthesize phosphaisocoumarin acids was developed via the reaction of phosphaisocoumarin esters with Me₃SiBr in chloroform followed by treatment with methanol, or with Me₃SiCl and NaI in acetonitrile followed by hydrolysis, under mild conditions in good to excellent yields.

Key words

synthesis - hydrolysis - dealkylation - phosphorus heterocycle

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