The Stereoselective Synthesis
of the C6-C18 Fragment of Scytophycin C Employing
a Novel Synthetic Methodology

Jhillu S. Yadav; V. Sunitha; Basi V. Subba Reddy; E. Gyanchander

doi:10.1055/s-2008-1067219

PAPER

The Stereoselective Synthesis of the C6-C18 Fragment of Scytophycin C Employing a Novel Synthetic Methodology

Jhillu S. Yadav*, V. Sunitha, Basi V. Subba Reddy, E. Gyanchander
Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27160512; e-Mail: yadavpub@iict.res.in;

Abstract

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Abstract

A novel synthetic approach towards the stereoselective synthesis of the C6-C18 fragment of the biologically active antitumor agent scytophycin C is described. The synthesis involves Marouka allylation, base-catalyzed intramolecular conjugate addition, Wittig olefination, and a tandem allylation.

Key words

scytophycin - allylation - olefination - trans-2,6-disubstituted dihydropyran

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Referenzen

References

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