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Synthesis 2008(18): 2925-2928  
DOI: 10.1055/s-2008-1067237
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a Conformationally Constrained Phenylalanine Derivative by a Strategic Combination of Ring-Closing Enyne Metathesis and Diels-Alder Reaction

Sambasivarao Kotha*, Priti Khedkar
Department of Chemistry, Indian Institute of Technology - Bombay, Mumbai 400076, India
Fax: +91(22)5723480; e-Mail: srk@chem.iitb.ac.in;
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Publikationsverlauf

Received 29 April 2008
Publikationsdatum:
22. August 2008 (online)

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Abstract

An efficient route towards the synthesis of a conformationally constrained phenylalanine derivative is demonstrated using the strategic combination of ring-closing enyne metathesis and Diels­-Alder reaction as key steps.

Key words

constrained amino acid - phenylalanine - ring closure - metathesis - Diels-Alder

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