Synthesis of Norpandamarilactonines, Pandamarilactonines, and ­Pandanamine

Abstract

A facile route to naturally occurring (±)-norpandamarilactonines A and B, (±)-pandamarilactonines A-D, and pandanamine has been described from 3-methylfuran-2(5H)-one, with a reductive intramolecular aza-Michael-type addition as the key step.

3-methylfuran-2(5H)-one - condensation - intramolecular aza-Michael reaction - pandamarilactonines

References

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Many websites describe the occurrence and properties of P. amaryllifolius leaves.

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11

The stereochemical assignments of compounds 10, 14, 15, 17, and 18 are based on NMR parameters. [8]