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Planta Med 2008; 74(10): 1285-1287
DOI: 10.1055/s-2008-1074579
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Activity of Diterpenoids Isolated from the Aerial Parts of Elaeoselinum asclepium subsp. meoides

Sergio Rosselli1 , Antonella Maggio1 , Cristina Eiroa1 , Carmen Formisano2 , Maurizio Bruno1 , Carlo Irace3 , Carmen Maffettone3 , Nicola Mascolo3
  • 1Dipartimento di Chimica Organica, Università degli Studi di Palermo, Palermo, Italy
  • 2Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli ”Federico II”, Napoli, Italy
  • 3Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli ”Federico II”, Napoli, Italy
Further Information

Publication History

Received: January 28, 2008 Revised: May 15, 2008

Accepted: May 18, 2008

Publication Date:
04 July 2008 (online)

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Abstract

The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid (5), new in the literature. The cytotoxic activities of elasclepic acid (1), ent-atis-16-en-19-oic acid (2), ent-beyer-15-en-19-oic acid (3), ent-kaur-16-en-19-oic acid (4) and meoidic acid (5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.

Key words

Elaeoselinum asclepium subsp. meoides - Umbelliferae - diterpenoids - meoidic acid - cytotoxic activity

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Prof. Maurizio Bruno

Dipartimento di Chimica Organica

Università degli Studi di Palermo

Viale delle Scienze

Parco d’Orleans II

90128 Palermo

Italy

Phone: +39/091/596/905

Fax: +39/091/596/825

Email: bruno@dicpm.unipa.it