Kardiologie up2date 2008; 4(4): 289-295
DOI: 10.1055/s-2008-1077750
Hotline – Risikofaktoren

© Georg Thieme Verlag KG Stuttgart · New York

Welchen Risiko-Score verwenden – ESC-SCORE, Framingham-Score, PROCAM oder CARRISMA?

Helmut  Gohlke
Further Information

Publication History

Publication Date:
30 December 2008 (online)

Abstract

The assessment of overall cardiovascular risk can be performed with one of four different algorithms: the PROCAM algorithm, the ESC-SCORE (Systematic Coronary Risk Evaluation) or the Framingham risk score. The PROCAM-Score and the Framingham risk score emphasize more cholesterol-dependent events, the ESC-SCORE more blood pressure dependent events and CARRISMA utilizes the additional prognostic importance of life style factors on top of the three risk algorithms. Severe obesity (BMI > 35) as well as heavy smoking (40 cig/day) doubles the cardiovascular risk compared to a BMI of 25 or "average" smoking of 15 cig/day respectively. Regular physical activity can reduce the cardiovascular risk up to 40%. If the 10 year risk of myocardial infarction exceeds 20% or of cardiovascular letality 5% respectively an intensified prevention is cost effective and the Number Needed to Treat (NNT) is usually < 200.

Literatur

  • 1 Heidrich J, Wellmann J, Hense H-W. et al . Klassische Risikofaktoren für Herzinfarkt und Gesamtsterblichkeit in der Bevölkerung. 13-Jahres-Follow-up der MONICA Augsburg-Kohortenstudie.  Z Kardiol. 2003;  92 445-454
  • 2 www.chd-taskforce.de. Internetseite zur automatischen Bestimmung des 10-Jahres-Risikos für Herzinfarkt. 
  • 3 Yusuf S, Hawken S, Ounpuu S. et al. on behalf of the INTERHEART Study Investigators . Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): a case-control study.  Lancet. 2004;  364 937-952
  • 4 Assmann G, Cullen P, Schulte H. Simple Scoring Scheme for Calculating the Risk of Acute Coronary Events Based on the 10-Year Follow-Up of the Prospective Cardiovascular Münster (PROCAM) Study.  Circulation. 2002;  105 310-315
  • 5 Hense H W, Schulte H, Löwel H. et al . Framingham risk function overestimates risk of coronary heart disease in men and women from Germany. Results from the MONICA Augsburg cohort and the PROCAM cohorts.  Eur Heart J. 2003;  24 937-945
  • 6 Stamler J, Stamler R, Neaton J D. et al . Low Risk-Factor Profile and Long-term Cardiovascular and Noncardiovascular Mortality and Life Expectancy: Findings for 5 Large Cohorts of Young Adult and Middle-Aged Men and Women.  JAMA. 1999;  282 2012-2018
  • 7 National Cholesterol Education Program. Adult Treatment Panel III.  JAMA. 2001;  285 2486-2495
  • 8 Conroy R M, Pyörälä K, Fitzgerald A P. et al . Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project.  Eur Heart J. 2003;  24 987-1003
  • 9 Keil U, Fitzgerald A P, Gohlke H. et al . Risikoabschätzung tödlicher Herz-Kreislauferkrankungen – Die neuen SCORE-Deutschland-Tabellen für die Primärprävention.  Dtsch Arztebl. 2005;  102 A1808-1812
  • 10 Gohlke H, Albus C, Bönner G. et al .Pocket-Leitlinien: Risikoadjustierte Prävention von Herz und Kreislauferkrankungen. Aktuelle Version der Empfehlungen zur Prävention über www.dgk.org/leitlinien . 2008
  • 11 Tuomilehto J, Lindstrom J, Eriksson J G. et al . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.  N Engl J Med. 2001;  344 1343-1350
  • 12 Gotto A M. for the AFCAPS/TexCAPS Research Group . Primary prevention of acute Coronary events with Lovastatin in men and women with average Cholesterol levels. Results of AFCAPS/TexCAPS.  JAMA. 1998;  279 1615-1622
  • 13 Greving J P, Buskens E, Koffijberg H, Algra A. Cost-effectiveness of aspirin treatment in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and varying cardiovascular risk.  Circulation. 2008;  117 2875-2883

Prof. Dr. med. Helmut Gohlke

Chefarzt Klinische Kardiologie II
Herz-Zentrum Bad Krozingen

Südring 15
79189 Bad Krozingen

Email: helmut.gohlke@herzzentrum.de