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Synlett 2008(14): 2132-2136
DOI: 10.1055/s-2008-1078240
DOI: 10.1055/s-2008-1078240
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Metal-Free Reductive Cleavage of N-O Bonds in Weinreb Amides by an Organic Neutral Super-Electron Donor
Further Information
Received
2 June 2008
Publication Date:
31 July 2008 (online)
Publication History
Publication Date:
31 July 2008 (online)
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Abstract
The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.
Key words
electron transfer - Weinreb amide - reduction - pyridinylidene
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