Perinatal Cerebral Arterial Infarction Associated with a Placental Chorioangioma

ABSTRACT

Placental chorioangiomas are benign vascular tumors. Large chorioangiomas cause several obstetric complications, including premature labor, placental abruption, polyhydramnios, fetal hydrops,[1] fetal growth restriction,[2] fetal hepatosplenomegaly, cardiomegaly, congestive heart failure, and fetal death.[3] The neonatal complications are hydrops fetalis, microangiopathic hemolytic anemia, and thrombocytopenia. The cause of perinatal cerebral arterial infarction remains unclear in the majority of cases.[4] [5] Investigators have reported a number of obstetric and neonatal complications in the setting of perinatal stroke, including birth asphyxia,[3] preeclampsia, chorioamnionitis, cardiac anomalies, polycythemia, systemic infection, and genetic thrombophilias.[6] We present a rare case of perinatal cerebral infarction associated with placental chorioangioma.

Chorioangioma - cerebral artery - hemorrhage

REFERENCES

• 1 Sweet L, Reid W D, Robertson N R. Hydrops fetalis in association with chorioangioma of the placenta.  J Pediatr. 1973;  82(1) 91-94
• 2 King C R, Lovrien E W. Chorioangioma of the placenta and intrauterine growth failure.  J Pediatr. 1978;  93(6) 1027-1028
• 3 Hurwitz A, Milwidsky A, Yarkoni S, Palti Z. Severe fetal distress with hydramnios due to chorioangioma.  Acta Obstet Gynecol Scand. 1983;  62(6) 633-635
• 4 Bejar R, Wozniak P, Allard M et al.. Antenatal origin of neurologic damage in newborn infants. I. Preterm infants.  Am J Obstet Gynecol. 1988;  159(2) 357-363
• 5 Ment L R, Duncan C C, Ehrenkranz R A. Perinatal cerebral infarction.  Ann Neurol. 1984;  16 559-568
• 6 Gunther G, Junker R, Strater R et al.. Symptomatic ischemic stroke in full term neonates: role of acquired and genetic prothrombotic risk factors.  Stroke. 2000;  31 2437-2441
• 7 Wallenburg H C. Chorioangioma of the placenta. Thirteen new cases and a review of the literature from 1939 to 1970 with special reference to the clinical complications.  Obstet Gynecol Surv. 1971;  26(6) 411-425
• 8 Hadi H A, Finley J, Strickland D. Placental chorioangioma: prenatal diagnosis and clinical significance.  Am J Perinatol. 1993;  10(2) 146-149
• 9 Batukan C, Holzgreve W, Danzer E, Bruder E, Hosli I, Tercanli S. Large placental chorioangioma as a cause of sudden intrauterine fetal death. A case report.  Fetal Diagn Ther. 2001;  16(6) 394-397
• 10 Mcinroy R A, Kelsey H A. Chorioangioma (haemangioma of placenta) associated with acute hydramnios.  J Pathol Bacteriol. 1954;  68(2) 519-523
• 11 Begg J D. A further case of chorioangioma.  J Obstet Gynaecol Br Commonw. 1961;  68 229-230
• 12 Brain M C, Dacie J V, Hourihane D O. Microangiopathic hemolytic anemia: the possible role of vascular lesions in pathogenesis.  Br J Haematol. 1962;  8 358-374
• 13 Bauer C R, Fojaco R M, Bancalari E, Fernandez-Rocha L. Microangiopathic hemolytic anemia and thrombocytopenia in a neonate associated with a large placental chorioangioma.  Pediatrics. 1978;  62(4) 574-577
• 14 Harigaya A, Nako Y, Morikawa A, Okano H, Takagi T. Premature infant with severe periventricular leukomalacia associated with a large placental chorioangioma: a case report.  J Perinatol. 2002;  22(3) 252-254
• 15 Koelfen W, Freund M, Varnholt V. Neonatal stroke involving the middle cerebral artery in term infants: clinical presentation, EEG and imaging studies and outcome.  Dev Med Child Neurol. 1995;  37 204-212
• 16 Wulfeck B B, Trauner D A, Tallal P A. Neurologic, cognitive, and linguistic features of infants after early stroke.  Pediatr Neurol. 1991;  7 266-269
• 17 Barmada M A, Moossy J, Shuman R M. Cerebral infarcts with arterial occlusion in neonates.  Ann Neurol. 1979;  6 495-502
• 18 Ghidini A, Locatilli A. Diffuse placental chorioangiomatosis causing multiple fetal cerebral embolisms: a case report.  J Reprod Med. 2006;  51(4) 321-324