New Labdane Diterpenes from Leonurus cardiaca

Abstract

Leonurus cardiaca L. has been used in oriental medicine against several types of disorders. The ethanolic extract of leaves of Leonurus cardiaca yielded three new labdane-type diterpenes: 15-O-ethylleopersin C (1), 15-O-methylleopersin C (2), and 15-epi-O-methylleopersin C (3). Their structures were determined using 1 D and 2 D NMR including ¹H-¹H COSY, HMQC, HMBC, and ROESY spectroscopic techniques. Compounds (1 – 3) were evaluated for in vitro antiplasmodial activity (D6 and W2 clones) and cytotoxicity (Vero cells).

Leonurus cardiaca - Lamiaceae - labdane diterpenes

References

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