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Planta Med 2008; 74(10): 1288-1290
DOI: 10.1055/s-2008-1081304
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

New Labdane Diterpenes from Leonurus cardiaca

Vijai K. Agnihotri1 , 3 , Hala N. ElSohly1 , Troy J. Smillie1 , Ikhlas A. Khan1 , 2 , Larry A. Walker1
  • 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, USA
  • 2Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi, USA
  • 3Current address: Pharmacopoeial Laboratory for Indian Medicine, Kamla Nehru Nagar, Ghaziabad, India
Further Information

Publication History

Received: January 10, 2008 Revised: May 13, 2008

Accepted: May 18, 2008

Publication Date:
29 July 2008 (online)

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Abstract

Leonurus cardiaca L. has been used in oriental medicine against several types of disorders. The ethanolic extract of leaves of Leonurus cardiaca yielded three new labdane-type diterpenes: 15-O-ethylleopersin C (1), 15-O-methylleopersin C (2), and 15-epi-O-methylleopersin C (3). Their structures were determined using 1 D and 2 D NMR including 1H-1H COSY, HMQC, HMBC, and ROESY spectroscopic techniques. Compounds (1 – 3) were evaluated for in vitro antiplasmodial activity (D6 and W2 clones) and cytotoxicity (Vero cells).

Key words

Leonurus cardiaca - Lamiaceae - labdane diterpenes

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Prof. Dr. Ikhlas A. Khan

National Center for Natural Products Research

University of Mississippi

University

Mississippi 38677

USA

Phone: +1-662-915-7821

Fax: +1-662-915-7989

Email: ikhan@olemiss.edu

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