Abstract
Four new furofurano lignans, lantibesides B – D (1 – 3) and lantibetin (4), along with nine known phenolic compounds were isolated from the EtOH extract of the traditional Tibetan medicinal plant, Lancea tibetica. By means of spectroscopic and chemical methods, the structures of the new compounds were elucidated as (1R,2S,5R,6S)-2-(3,4-methylenedioxyphenyl)-6-[(3-methoxy-4-β-D-xylopyranosyloxy(1→6)-β-D-glucopyranosyloxy)phenyl]-3,7-dioxabicyclo[3.3.0]octane (1), (1R,2R,5R,6S)-2-(3,4-methylenedioxyphenyl)-6-[(3-methoxy-4-β-D-xylopyranosyloxy(1→6)-β-D-glucopyranosyloxy)phenyl]-3,7-dioxabicyclo [3.3.0]octane (2), (1R,2R,5R,6S)-2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-β-D-glucopyranosyloxy)phenyl-3,7-dioxabicyclo[3.3.0]octane (3), and (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0] octane (4). Compounds 2 and 3 showed weak cytotoxicity against the HL-60 cell line with IC50 values of 61 and 99 μM, respectively.
Key words
Lancea tibetica
- Phrymaceae - cytotoxicity - furofurano lignin - lantibeside - lantibetin
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Prof. Dr. Wei Ming Zhu
School of Medicine and Pharmacy
Ocean University of China
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